The price is that a small percentage of electrons “leak” prematurely, leading to the formation of oxidizing intermediates. This mechanism is the mitochondrial electron transport chain. In fact, in order to use molecular oxygen as the final electron acceptor in mitochondrial respiration, it was necessary to develop a mechanism by which paired electrons from coenzymes (NADH, FADH 2) could be delivered, not in pairs, but one by one to molecular oxygen. ![]() However, the use of molecular oxygen in cellular respiration had its price. In order to have an idea of this increase in efficiency, it is sufficient to compare the ATP yield in anaerobic fermentation for a glucose molecule (2 ATPs) with its complete oxidation in aerobic respiration (32 ATPs). It made the process more energetically efficient, thus promoting the development of higher animals. The evolution from anaerobic to aerobic respiration brought great benefits to the evolution of organisms. Ximenes, in Studies in Natural Products Chemistry, 2018 Molecular Oxygen, Spin Restriction, and Physiological Generation of ROS
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